Propolis

Used by the Egyptian civilization for the embalming of the dead, propolis was also highly prized by the Inca, Greek and Roman civilizations to detoxify and strengthen attacked tissues.

The first scientific study was carried out in 1928. In the last 30 years, more than 2500 scientific articles have been published on propolis.

Propolis has been studied by many great scientists, such as Pr Rémy Chauvin, French biologist and entomologist, specialist in insect behaviour, as well as Dr John Diamond, creator of behavioural kinesiology, who validated the use of propolis during kinesiology tests in his patients, to strengthen the thymus (immune gland and interface between body and mind).

It should be noted that bees have been present on our earth for more than 125 million years.

Propolis actions :

• reinforces the vitality of the various players in our defences

• damages and damages the cell membrane of microorganisms.

• decreases the mobility and vigour of micro-organisms

• decomposes the formation of biofilms that surround microorganisms in order to escape the vigilance of natural defences

• reduces the production of fuel (ATP) used by micro-organisms

Propolis and Inflammation

Propolis regulates the main markers of cellular and tissue reactions to aggression:

• Prostaglandin E2 (PGE2)

• 5-Lipoxygenase (5-LOX)

Arachidonic acid cascade: saturated fatty acid constituting membranes of our cells and substrate for the manufacture of pro-inflammatory molecules.

The content of saturated and trans fats in our diet determines the level of inflammation in the body.

Propolis, aggression and tissue regeneration

During a tissue aggression, the results show that after 14 to 21 days, propolis allowed the recruitment of essential growth factors and their migration on the aggressed areas and tissues to allow their re-pithelization.

Department of Anesthetic Surgery and Radiology. Faculty of Veterinary Medicine. Cairo University. 2015

Propolis and Teeth

Propolis rich in galangin has a detoxifying action by acting on microorganisms.

Propolis and autophagy

Scientific studies show that galangin acts on a unique and natural mechanism called "autophagy" of selection and detoxification of used cells.

Autophagy is a natural mechanism that is highly studied by scientists and is regulated by the cell. It has a self-digestion and self-destruction mechanism when its functioning or viability (survival) is no longer assured.

Fostering and stimulating autophagy represents a relevant therapeutic option and strategy for researchers in the fight against destabilized, aggressive, non-viable cells for the organism.

Autophagy is a system of intracellular degradation of the cytoplasm, accompanied by organelles that are sequestered in vesicles, called autophagosomes. These will transmit the debris to the lysosomes so that it can be permanently degraded or recycled.

This mechanism removes a significant amount of cellular stress and toxin overload from the cell and the body.

Autophagy is important in the life cycle of the cell, in its development and differentiation. It allows the maintenance of tissue coherence and the emergence of cellular vital energy.

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Institute of Microbiological Chemistry. Shinagawa. Tokyo. 2016

University of Michigan. Institute of Life Sciences. 2016

Chemistry department. St. Peter's University. Jersey City. USA. 2016

Department of Parasitology. Namik Kemal Teki-day University. Turkey.

Department of Physiological Sciences of Campinas. Paricicaba. 2016

Department of Pediatric Dentistry and Orthodontics. Federal University of Rio de Janeiro. Brazil. 2016